Er:YAG 레이저와 Er,Cr:YSGG 레이저가 염증유발 마우스조직에 미치는 영향
The Effect of ER:YAG Laser & ER,CR:YSGG Laser on the Tissue of the Inflammation-Induced Mouse
박태일, 이형석, 이희종, 채창훈, 이영주, 변광섭, 홍순민, 최미라, 박준우,
소속 상세정보
박태일 ( Park Tae-Il ) - 한림대학교 의학과 대학원
이형석 ( Lee Hyung-Seok ) - 한림대학교 의학과 대학원
이희종 ( Lee Hee-Jong ) - 한림대학교 의학과 대학원
채창훈 ( Chae Chang-Hoon ) - 한림대학교 임상치의학대학원
이영주 ( Lee Young-Joo ) - 한림대학교 강동성심병원 구강악안면외과
변광섭 ( Byeon kwang-Seob ) - 한림대학교 강동성심병원 구강악안면외과
홍순민 ( Hong Soon-Min ) - 한림대학교 강동성심병원 구강악안면외과
최미라 ( Choi Mee-Ra ) - 한림대학교 의과대학 강동성심병원 보철과
박준우 ( Park Jun-Woo ) - 한림대학교 강동성심병원 구강악안면외과
KMID : 0360120100320050396
Abstract
Purpose:This study was performed to find out the effects of the Er:YAG laser (Key Laser) & Er,Cr:YSGG laser (Water Laser) on inflammatory tissues .
Methods:It was performed on about 20 g, 6 weeks male ICR mouses. They were grouped into the control (negative), the inflammation induced ‘control’(positive), Er,Cr:YSGG laser exposured group after inducing inflammation, Er:YAG lasere exposured group after inducing inflammation each 15 mouses. The mouses were applicated 0.5% DNFB 1 cc on ear skin twice a day for 4 days until symptom expression. After laser exposure, ear tissues were extracted and defined gene expression by RT-PCR. Then, tissue staining, lymphocytes observation, electromicroscophic laboratory were carried out.
Results:Interleukin-1βwas expressed much less in the A-laser exposed group. Interleukin-1β& Tumor Necrosis Factor-αwere expressed 7 times lesser in the A-laser exposed group. The number of Lymphocytes related to inflammation was decreased rapidly in the A-laser exposed group in vivo. he number of cavity recovered normal was a little bigger in the A-laser exposed group after 5 days.
Conclusions: The expression of IL-1β& TNF-α, hitologic change, observation with electron microscope shows that Erbium laser exposure causes lesser inflammation with A-laser rather than B-laser.
키워드
Laser therapy; IL-1β& TNF-α; Mice; Electron microscope
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